Vacquinol-1
Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells; induces rapid and specific cell death of glioma cells via membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture; shows good brain penetrance and excellent pharmacokinetics; orally bioactive.
Product Specifications
CAS Number
5428-80-8
Product Name Alternative
NSC 13316
Purity
>98% (HPLC)
Solubility
Ethanol: <1 mg/mL; DMSO: 70 mg/mL (164.4 mM) ; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
ClC1=CC=C (C2=NC (C=CC=C3) =C3C (C (O) C4NCCCC4) =C2) C=C1
Molecular Formula
C21H21ClN2O
Molecular Weight
352.862
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
[2- (4-Chlorophenyl) quinolin-4-yl] (piperidine-2-yl) methanol
Available Sizes
Frequently Asked Questions
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