CASIN
CASIN is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer[1][2].
Product Specifications
CAS Number
425399-05-9
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Ras
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CASIN.html
Purity
99.89
Solubility
DMSO : ≥ 31 mg/mL
Smiles
OCCNC1C(NC2=C3C=C(C4=CC=CC=C4)C=C2)=C3CCC1
Molecular Formula
C20H22N2O
Molecular Weight
306.40
Precautions
H315, H319, H335
References & Citations
[1]Florian MC et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell, 2012 May 4, 10 (5) :520-30.|[2]Nguyen P, et al. Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Front Oncol. 2019 Oct 1;9:958. doi: 10.3389/fonc.2019.00958.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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