SW-033291
A potent and selective inhibitor of 15-PGDH with Ki of 0.1 nM, IC50 of 1.5 nM; increases PGE2 levels by 3.5-fold at 500 nM, with EC50 of 75 nM; increases prostaglandin PGE2 levels in bone marrow and other tissues, accelerates hematopoietic recovery in mice receiving a bone marrow transplant; also promotes tissue regeneration in mouse models of colon and liver injury.
Product Specifications
CAS Number
459147-39-8
Product Name Alternative
SW033291
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
NC1=C (S (CCCC) =O) SC2=NC (C3=CC=CS3) =CC (C4=CC=CC=C4) =C21
Molecular Formula
C21H20N2OS3
Molecular Weight
412.5913
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Thieno[2,3-b]pyridin-3-amine, 2- (butylsulfinyl) -4-phenyl-6- (2-thienyl) -
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