SCH-527123
A potent, selective, orally bioavailable CXCR2/CXCR1 receptor antagonist with Kd of 0.08 and 41 nM for cynomolgus CXCR2 and CXCR1, respectively; potently inhibits CXCR2-mediated chemotaxis with IC50 of 3-6 nM; inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation.COPD Phase 2 Discontinued.
Product Specifications
CAS Number
473727-83-2
Product Name Alternative
SCH527123 | Navarixin | SCH 527123 | MK-7123
Field of Research
Signal Transduction
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (N (C) C) C1=CC=CC (NC2=C (N[C@@H] (C3=CC=C (C) O3) CC) C (C2=O) =O) =C1O
Molecular Formula
C21H23N3O5
Molecular Weight
397.4244
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, 2-hydroxy-N, N-dimethyl-3-[[2-[[ (1R) -1- (5-methyl-2-furanyl) propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-
Available Sizes
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