Tivozanib
A highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3; also inhibits EphB2, PDGFR-α, PDGFR-β, c-Kit, and Tie2 (IC50=20-80 nM) ; inhibits VEGF-induced VEGFR-2 phosphorylation in endothelial cells (IC50=0.16 nM) ; p.o. active.Kidney Cancer Approved.
Product Specifications
CAS Number
475108-18-0
Product Name Alternative
AV-951 | AV951 | AV 951
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC1=NOC (C) =C1) NC2=CC=C (OC3=CC=NC4=CC (OC) =C (OC) C=C34) C=C2Cl
Molecular Formula
C22H19ClN4O5
Molecular Weight
454.8631
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Urea, N-[2-chloro-4-[ (6,7-dimethoxy-4-quinolinyl) oxy]phenyl]-N'- (5-methyl-3-isoxazolyl) -
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