AR-A014418
A potent, specific ATP-competitive inhibitor of GSK-3β with Ki/IC50 of 38/104 nM; shows no significantly inhibition on CDK2, CDK5 (IC50>100 uM) or 26 other kinases; inhibits tau phosphorylation at a GSK3-specific site (Ser-396) in cells and protects N2A neuroblastoma cells against cell death mediated by inhibition of PI3K/Akt pathway.
Product Specifications
CAS Number
487021-52-3
Product Name Alternative
AR-AO 14418 | AR 0133418 | AR 014418 | GSK 3β inhibitor
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
COc1ccc (cc1) CNC (=O) Nc2ncc (s2) [N+] (=O) [O-]
Molecular Formula
C12H12N4O4S
Molecular Weight
308.3131
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Urea, N-[ (4-methoxyphenyl) methyl]-N'- (5-nitro-2-thiazolyl) -
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