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AR-A014418

A potent, specific ATP-competitive inhibitor of GSK-3β with Ki/IC50 of 38/104 nM; shows no significantly inhibition on CDK2, CDK5 (IC50>100 uM) or 26 other kinases; inhibits tau phosphorylation at a GSK3-specific site (Ser-396) in cells and protects N2A neuroblastoma cells against cell death mediated by inhibition of PI3K/Akt pathway.

Product Specifications

CAS Number

487021-52-3

Product Name Alternative

AR-AO 14418 | AR 0133418 | AR 014418 | GSK 3β inhibitor

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

COc1ccc (cc1) CNC (=O) Nc2ncc (s2) [N+] (=O) [O-]

Molecular Formula

C12H12N4O4S

Molecular Weight

308.3131

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Urea, N-[ (4-methoxyphenyl) methyl]-N'- (5-nitro-2-thiazolyl) -

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