AEE-788
A potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively; inhibits growth factor-induced EGFR and ErbB2 phosphorylation in cells with IC50 of 11 and 220 nM, respectively, demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines; shows antitumor and antiangiogenic activity in vivo.Brain Cancer Phase 2 Discontinued.
Product Specifications
CAS Number
497839-62-0
Product Name Alternative
AEE 788 | AEE788 | NVP-AEE 788
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM
Smiles
C[C@@H] (NC1=C2C (NC (C3=CC=C (CN4CCN (CC) CC4) C=C3) =C2) =NC=N1) C5=CC=CC=C5
Molecular Formula
C27H32N6
Molecular Weight
440.5832
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-[4-[ (4-ethyl-1-piperazinyl) methyl]phenyl]-N-[ (1R) -1-phenylethyl]-
Available Sizes
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