EX 527 (Selisistat)
EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3. (In Vitro) :Selisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells. (In Vivo) :Selisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD) .
Product Specifications
CAS Number
49843-98-3
Product Name Alternative
Selisistat
Purity
>98% (HPLC)
Solubility
DMSO:50 mg/mL (201.03 mM) ; Ethanol:18 mg/mL (72.37 mM) ; Water:<1 mg/mL (<1 mM)
Smiles
O=C (C1C (NC2=C3C=C (Cl) C=C2) =C3CCC1) N
Molecular Formula
C13H13ClN2O
Molecular Weight
248.71
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Available Sizes
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