Dexamethasone (DHAP)
Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects (In Vitro) :MK-3207 (0.3, 0.6, 1.1, 2.3, 4.5, 9.0 nM; 30 min) potently blocks human α-CGRP-stimulated cAMP responses in human CGRP receptor-expressing HEK293 cells. (In Vivo) :MK-3207 (0.3, 0.6, 2.1, 9.1, 21.2, 60.6 μg/kg; i.v.; single) inhibits CIDV in rhesus monkeys with EC50 and Emax values of approximately 0.8 nM and 81%.MK-3207 (10 mg/kg; p.o.; single) shows the CSF/plasma ratio is 2 to 3%.
Product Specifications
CAS Number
50-02-2
Product Name Alternative
DHAP
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 6 mg/mL (15.28 mM) ; DMSO: 79 mg/mL (201.29 mM)
Smiles
O=C1C=C[C@]2 (C) [C@@]3 (F) [C@@H] (O) C[C@]4 (C) [C@] (C (CO) =O) (O) [C@H] (C) C[C@@]4 ([H]) [C@]3 ([H]) CCC2=C1
Molecular Formula
C22H29FO5
Molecular Weight
392.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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