Corticosterone

Corticosterone is a sensitive inhibitor of monoamine transport. (In Vitro) :Corticosterone (100 nM; 30 min) via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane.Corticosterone (CORT) (1 μM; 48 h) shows good immunosuppressive properties (functionally compromises maturation of BMDC), which impairs LPS-induced up-regulation of maturation-associated markers (MHC class II, B7.2, B7.1 and CD40) . (In Vivo) :Corticosterone results in a marked reduction in the ability of BMDC cells to prime naive CD8+ T cells in vivo.Corticosterone (0.03 or 1 mg/kg; s.c.; single) downregulates expression of BDNF mRNA in dentate gyrus and CA1 of rats.Corticosterone (2.6 mg/kg; in animal feedings; 8 days) restores ethanol intake and preference to approximately normal preoperative levels in adrenalectomy (ADX) rats.

Product Specifications

CAS Number

50-22-6

Product Name Alternative

17-deoxy Cortisol | 11β,21-DHP | NSC 9705 | 11β,21-dihydroxy Progesterone

Purity

>98% (HPLC)

Solubility

Soluble in DMSO

Smiles

C[C@@]12[C@@H] (C (CO) =O) CC[C@@]1 ([H]) [C@]3 ([H]) CCC4=CC (CC[C@]4 (C) [C@@]3 ([H]) [C@@H] (O) C2) =O

Molecular Formula

C21H30O4

Molecular Weight

346.46

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

(8S,9S,10R,11S,13S,14S,17S) -11-hydroxy-17- (2-hydroxyacetyl) -10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one