IRAK-1-4 Inhibitor I
IRAK-1-4 Inhibitor I is a potent, dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 uM and 0.3 uM, respectively; displays IC50 of >10 uM against a panel of 27 other kinases, including the most closely homologous (outside of the IRAK family) Lck and pp60SRC; eliminates the LPS-induced increases in Bcl10, NF-κB, and IL-8 in human intestinal epithelial cells.
Product Specifications
CAS Number
509093-47-4
Product Name Alternative
IRAK-1/4 Inhibitor I
Field of Research
Immunology & Inflammation; Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC1=NC2=CC=CC=C2N1CCN3CCOCC3) C4=CC=CC ([N+] ([O-]) =O) =C4
Molecular Formula
C20H21N5O4
Molecular Weight
395.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[1-[2- (4-morpholinyl) ethyl]-1H-benzimidazol-2-yl]-3-nitro-
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