Mizoribine
An immunosuppressive agent that inhibits the proliferation of lymphocytes selectively, via inhibition of IMPDH.Rheumatoid Arthritis Approved (In Vitro) :Mizoribine, isolated from culture medium of the mold Eupenicillium brefeldianum M-2166, acts as an immunosuppressant which exerts its effects without severe side effects.Mizoribine is an inosine-5′-monophosphate dehydrogenase (IMPDH) inhibitorused for renal transplantation, autoimmune diseases and steroid-resistant nephrotic syndrome . (In Vivo) :Mizoribine suppresses collagen-induced arthritis. Mizoribine (10, 20 and 50 mg/kg; Administered orally 5 days a week for 12 weeks) reduces the arthritis score in a dose-dependent fashion, showing significant suppression, even at a dose of 10 mg/kg.
Product Specifications
CAS Number
50924-49-7
Product Name Alternative
NSC-289637 | HE-69
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 35 mg/mL
Smiles
O=C (C1=C (O) N ([C@@H]2O[C@H] (CO) [C@@H] (O) [C@H]2O) C=N1) N
Molecular Formula
C9H13N3O6
Molecular Weight
259.216
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Imidazole-4-carboxamide, 5-hydroxy-1-β-D-ribofuranosyl-
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