Didanosine
Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. (In Vitro) :Didanosine is converted by cellular enzymes to the active antiviral metabolite dideoxyadenosine triphosphate (dd-ATP) and the intracellular half life of dd-ATP varies from 8-24 hours.Didanosine shows antiretroviral activity with IC50 value of 0.24-0.6 mg/L for HIV infection.Didanosine (5, 10, 50, 100 ug/ml; 24, 48 h) shows no significant inhibition of cell proliferation in IEC-6 cells. (In Vivo) :Didanosine (100, 150 mg/kg; p.o.; daily for 7 days) decreases the length of duodenal and in jejunal villus in mouse.
Product Specifications
CAS Number
69655-05-6
Product Name Alternative
NSC 612049
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 47 mg/mL (198.95 mM)
Smiles
C1C[C@@H] (O[C@@H]1CO) N2C=NC3=C2NC=NC3=O
Molecular Formula
C10H12N4O3
Molecular Weight
236.23
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
9-[ (2R,5S) -5- (hydroxymethyl) oxolan-2-yl]-3H-purin-6-one
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