Neratinib
A potent, highly selective, irreversible HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src (IC50=0.8 and 1.4 uM), no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met; inhibits downstream signal transduction events and cell cycle regulatory pathways, leads to arrest at the G (1) -S phase transition, decreases cell proliferation; active in HER-2- and EGFR-dependent tumor xenograft models, orally bioavailable.Breast Cancer Approved.
Product Specifications
CAS Number
698387-09-6
Product Name Alternative
HKI-272 | HKI272 | HKI 272
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 6.4 mg/mL (Need ultrasonic)
Smiles
CCOC1=C (C=C2C (=C1) N=CC (=C2NC3=CC (=C (C=C3) OCC4=CC=CC=N4) Cl) C#N) NC (=O) /C=C/CN (C) C
Molecular Formula
C30H29ClN6O3
Molecular Weight
557.0427
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Butenamide, N-[4-[[3-chloro-4- (2-pyridinylmethoxy) phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4- (dimethylamino) -, (2E) -
Available Sizes
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