Didox

A ribonucleotide reductase inhibitor; overcomes Bcl-2 mediated radiation resistance in PC-3 cells; induces apoptosis and inhibits DNA repair in multiple myeloma cells by downregulation of bcl family proteins including bcl-2, bcl (xl), and XIAP; (150 mg/kg daily) significantly protects the cardiomyocyte membrane integrity and decreases the intra-cardiac oxidative stress induced by DOX treatment (15 mg/kg) in mice.