BX795
BX795 is a potent and relatively specific PDK1 inhibitor with IC50 of 6 nM; also inhibits TBK1 and IKKε with IC50 of 6 nM and 41 nM; shows no activity for PKA, PKC, c-Kit, GSK3β, IKKα, IKKβ, etc.; blocks the autophosphorylation of overexpressed TBK1 and IKKepsilon at Ser-172; has no effect on the canonical NFkappaB signaling pathway.
Product Specifications
CAS Number
702675-74-9
Product Name Alternative
BX 795 | BX-795
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (N1CCCC1) NC2=CC=CC (NC3=NC=C (I) C (NCCCNC (C4=CC=CS4) =O) =N3) =C2
Molecular Formula
C23H26IN7O2S
Molecular Weight
591.4677
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Pyrrolidinecarboxamide, N-[3-[[5-iodo-4-[[3-[ (2-thienylcarbonyl) amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-
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