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Vinorelbine

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM; induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.Chemotherapeutic Agents Approved.

Product Specifications

CAS Number

71486-22-1

Product Name Alternative

KW-2307

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

CCC1=C[C@H]2C[C@@] (C3=C (CN (C2) C1) C4=CC=CC=C4N3) (C5=C (C=C6C (=C5) [C@]78CCN9[C@H]7[C@@] (C=CC9) ([C@H] ([C@@] ([C@@H]8N6C) (C (=O) OC) O) OC (=O) C) CC) OC) C (=O) OC

Molecular Formula

C45H54N4O8

Molecular Weight

778.9323

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Aspidospermidine-3-carboxylic acid, 4- (acetyloxy) -6,7-didehydro-15-[ (2R,6R,8S) -4-ethyl-1,3,6,7,8,9-hexahydro-8- (methoxycarbonyl) -2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α) -

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