JSH-23
JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM. (In Vitro) :JSH-2 (1-300 μM; 24 hours) at <100 μM does not show significant cytotoxic effects on the RAW 264.7 cells.Nuclear amount of NF-κB p65 is markedly increased upon exposure to LPS for 1 h. Treatment of JSH-23 (30 μM; 1 hours) to LPS- stimulated RAW 264.7 cells decreases nuclear content of NF-κB p65 in a dose-dependent manner. (In Vivo) :JSH-23 (1 mg/kg, 3 mg/kg; orally administered; daily; for 2 weeks) significantly reverses the nerve conduction and nerve blood flow deficits seen in diabetic rats.
Product Specifications
CAS Number
749886-87-1
Product Name Alternative
NF-κB Activation Inhibitor II
Purity
>98% (HPLC)
Solubility
Ethanol: 20 mg/mL (83.21 mM) ; DMSO: 48 mg/mL (199.71 mM)
Smiles
NC1=CC (C) =CC=C1NCCCC2=CC=CC=C2
Molecular Formula
C16H20N2
Molecular Weight
240.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-methyl-N1- (3-phenylpropyl) benzene-1,2-diamine
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