Volasertib
Volasertib (BI 6727) is a potent, selective Polo-like kinase (PLK) inhibitor with IC50 of 0.87, 5 and 56 nM for PLK1, 2 and 3, respectively; displays no inhibitory activity against a panel of >50 other kinases; inhibits proliferation of multiple cell lines derived from various cancer tissues, including HCT116 (EC50=23 nM) and NCI-H460 (EC50=21 nM), BRO (EC50=11 nM), and hematopoietic cancer cell HL-60 (EC50=32 nM) ; demonstrates marked antitumor activity in multiple cancer models, including a model of taxane-resistant colorectal cancer.Blood Cancer Phase 3 Clinical.
Product Specifications
CAS Number
755038-65-4
Product Name Alternative
BI 6727 | BI-6727 | BI6727
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (N[C@H]1CC[C@@H] (N2CCN (CC3CC3) CC2) CC1) C4=CC=C (NC (N=C5N (C (C) C) [C@@H]6CC) =NC=C5N (C) C6=O) C (OC) =C4
Molecular Formula
C34H50N8O3
Molecular Weight
618.8126
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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