Isradipine

Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure. (In Vitro) :Isradipine has much higher (>40 fold) affinity for Cav1.3 channels as well as good brain bioavailability. Isradipine has nearly equal potency at Cav1.2 and Cav1.3 channels. (In Vivo) :Isradipine (0.1~3 mg/kg; p.o.) makes sodium excretion increase in a dose-dependent manner.Isradipine pre-treatment reduces 6-hydroxydopamine induced neurotoxicity at the striatal level. Protective effect of isradipine at the striatal level is dose-dependent as shown from 6 mice. Isradipine pre-treatment increases the number of surviving SNc DA cells after 6-hydroxydopamine induced degeneration. Isradipine is capable of protecting striatal dopaminergic terminals and SNc dopaminergic cell bodies against a slow, progressive insult created by intrastriatal injection of 6-hydroxydopamine.