Isradipine
Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure. (In Vitro) :Isradipine has much higher (>40 fold) affinity for Cav1.3 channels as well as good brain bioavailability. Isradipine has nearly equal potency at Cav1.2 and Cav1.3 channels. (In Vivo) :Isradipine (0.1~3 mg/kg; p.o.) makes sodium excretion increase in a dose-dependent manner.Isradipine pre-treatment reduces 6-hydroxydopamine induced neurotoxicity at the striatal level. Protective effect of isradipine at the striatal level is dose-dependent as shown from 6 mice. Isradipine pre-treatment increases the number of surviving SNc DA cells after 6-hydroxydopamine induced degeneration. Isradipine is capable of protecting striatal dopaminergic terminals and SNc dopaminergic cell bodies against a slow, progressive insult created by intrastriatal injection of 6-hydroxydopamine.
Product Specifications
CAS Number
75695-93-1
Product Name Alternative
PN 200-110
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 74 mg/mL warmed (199.25 mM) ; DMSO: 74 mg/mL (199.25 mM)
Smiles
CC1=C (C (OC) =O) C (C2=CC=CC3=NON=C32) C (C (OC (C) C) =O) =C (C) N1
Molecular Formula
C19H21N3O5
Molecular Weight
371.39
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-isopropyl 5-methyl 4- (benzo[c][1,2,5]oxadiazol-4-yl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Available Sizes
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