Arteether
Arteether, a new antimalarial drug. (In Vitro) :The antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration (IC50) for Artemotil is 1.61 nM (range 1.57-1.92 nM) . Artemotil is approximately 2.5-fold more potent than artemisinin. (In Vivo) :Artemotil treatment (25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats) shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours (day 1) to 31.2 hours (day 7) .
Product Specifications
CAS Number
75887-54-6
Product Name Alternative
Artemotil | Dihydroartemisinin ethyl ether | NSC 665971
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
C[C@H]1[C@@H] (OCC) O[C@@]2 ([H]) [C@]34[C@@] ([C@H] (C) CC[C@]41[H]) ([H]) CC[C@@] (O2) (C) OO3
Molecular Formula
C17H28O5
Molecular Weight
312.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(3R,5aS,6R,8aS,9R,10S,12R,12aR) -10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano (4,3-j) -1,2-benzodioxepin
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