NVP-TAE 684
A highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays; exhibits no significant cross-reactivity against other kinases; blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 2-10 nM, inhibits phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest; suppresses lymphomagenesis in in vivo models.Blood Cancer Discontinued.
Product Specifications
CAS Number
761439-42-3
Product Name Alternative
TAE-684 | TAE684 | NVP TAE684
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CN1CCN (C2CCN (C3=CC=C (NC4=NC=C (Cl) C (NC5=CC=CC=C5S (=O) (C (C) C) =O) =N4) C (OC) =C3) CC2) CC1
Molecular Formula
C30H40ClN7O3S
Molecular Weight
614.2017
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,4-Pyrimidinediamine, 5-chloro-N2-[2-methoxy-4-[4- (4-methyl-1-piperazinyl) -1-piperidinyl]phenyl]-N4-[2-[ (1-methylethyl) sulfonyl]phenyl]-
Available Sizes
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