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R-IMPP

R-IMPP (PF-00932239) is an anti-secretagogue of PCSK9 (IC50=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation[1].

Product Specifications

CAS Number

2133832-83-2

Product Name Alternative

PF-00932239

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/R-IMPP.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C1=NC=CC2=C1C=CC=C2)[C@H]3CNCCC3)CCC4=CC=C(OC)C=C4

Molecular Formula

C24H27N3O2

Molecular Weight

389.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23 (11) :1362-1371

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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