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GNF-2

A potent, allosteric, non-ATP competitive Bcr-Abl inhibitor that shows exclusive antiproliferative activity toward Bcr-abl-transformed cells; causes growth inhibition of Bcr-Abl positive cell lines with IC50s of 273 nM (K562) and 268 nM (SUP-B15) ; inhibits mutant Bcr-Abl E255V, Y253H cell growth.

Product Specifications

CAS Number

778270-11-4

Product Name Alternative

GNF 2 | GNF2

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 45 mg/mL

Smiles

O=C (N) C1=CC=CC (C2=NC=NC (NC3=CC=C (OC (F) (F) F) C=C3) =C2) =C1

Molecular Formula

C18H13F3N4O2

Molecular Weight

374.3166

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Benzamide, 3-[6-[[4- (trifluoromethoxy) phenyl]amino]-4-pyrimidinyl]-

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