YM-155
A potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM; does not significantly inhibit SV40 promoter activity (>30 uM) ; suppresses expression of survivin and induces apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nM, without effect on IAP- or Bcl-2-related proteins; induces massive tumor regression in PC-3 tumor mice model (3-10 mg/kg) .Blood Cancer Phase 1 Discontinued.
Product Specifications
CAS Number
781661-94-7
Product Name Alternative
YM155 | Sepantronium bromide | YM 155
Purity
>98% (HPLC)
Solubility
DMSO: 10.66 mg/mL
Smiles
O=C (C1=C2[N+] (CCOC) =C (C) N1CC3=NC=CN=C3) C4=C (C=CC=C4) C2=O.[Br-]
Molecular Formula
C20H19BrN4O3
Molecular Weight
443.2939
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1- (2-methoxyethyl) -2-methyl-4,9-dioxo-3- (2-pyrazinylmethyl) -, bromide (1:1)
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