NSC-59984
A small molecule that both destabilize mutant p53 and restores wild-type p53 pathway in cancer cells; induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway, restores wild-type p53 signaling via p73 activation, specifically in mutant p53-expressing colorectal cancer cells. degrades mutant p53R273H, rescued CDH6 expression; significantly represses DLD-1 xenograft tumor growth.
Product Specifications
CAS Number
803647-40-7
Product Name Alternative
NSC 59984 | NSC59984
Field of Research
Neuroscience
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 38 mg/mL
Smiles
O=C (N1CCN (C) CC1) /C=C/C2=CC=C ([N+] ([O-]) =O) O2
Molecular Formula
C12H15N3O4
Molecular Weight
265.2652
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Propen-1-one, 1- (4-methyl-1-piperazinyl) -3- (5-nitro-2-furanyl) -
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