Roxadustat
Roxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM; FG-4592 stimulates erythropoiesis, regulates iron metabolism, and reduces hepcidin, demonstrates potential for treatment of anemia.Anemia Phase 3 Clinical (In Vitro) :Roxadustat (5-50 μM; 6 hours) significantly inhibits TBHP-induced apoptosis in PC12 cells.Roxadustat (50 μM; 6 hours) stabilizes HIF-1α protein expression in PC12 cells. (In Vivo) :Roxadustat (50 mg/kg; i.p.; daily for 7 days) protects the survival of motor neurons and improves recovery from spinal cord injury.
Product Specifications
CAS Number
808118-40-3
Product Name Alternative
FG4592 | FG-4592
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 46 mg/mL
Smiles
O=C (O) CNC (C1=C (O) C2=C (C (C) =N1) C=C (OC3=CC=CC=C3) C=C2) =O
Molecular Formula
C19H16N2O5
Molecular Weight
352.3407
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Glycine, N-[ (4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl) carbonyl]-
Available Sizes
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