E3 Ligase Ligand-linker Conjugate 135
Product Specifications
UNSPSC Description
E3 Ligase Ligand-linker Conjugate 135 is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete PROTAC molecule pan-KRAS degrader 5 (HY-168678)[1].
Target Antigen
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugate-135.html
Smiles
O=C(NC1=O)CCC1N(C(N2C)=O)C(C=C3)=C2C=C3N(CC4)CCC4CN(CC5)CCC5CC6CCNCC6
Molecular Weight
536.71
References & Citations
[1]"Arvinas Operations, Inc., et al. Preparation of pyridopyrimidines as cereblon-based KRas degrading PROTACS and uses related thereto. World Intellectual Property Organization, WO2024159164 A2 2024-08-02
"
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168680/E3-Ligase-Ligand-linker-Conjugate-135-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168680/
Clinical Information
No Development Reported
CAS Number
3052748-49-6
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