E3 Ligase Ligand-linker Conjugate 135
E3 Ligase Ligand-linker Conjugate 135 is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete PROTAC molecule pan-KRAS degrader 5 (HY-168678) [1].
Product Specifications
CAS Number
[3052748-49-6]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugate-135.html
Smiles
O=C(NC1=O)CCC1N(C(N2C)=O)C(C=C3)=C2C=C3N(CC4)CCC4CN(CC5)CCC5CC6CCNCC6
Molecular Formula
C30H44N6O3
Molecular Weight
536.71
References & Citations
[1]"Arvinas Operations, Inc., et al. Preparation of pyridopyrimidines as cereblon-based KRas degrading PROTACS and uses related thereto. World Intellectual Property Organization, WO2024159164 A2 2024-08-02 "
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
More Discoveries
Explore Other Products
Browse additional items from our catalog
133539-ML750 100 µL
SMAD3 (Mothers Against Decapentaplegic Homolog 3, SMAD 3, Mothers Against DPP Homolog 3, MAD Homolog 3, Mad3, hMAD-3, SMAD Family Member 3, JV15-2, hSMAD3, MADH3, DKFZp586N0721, DKFZp686J10186, HSPC193, HsT17436, MGC60396) (MaxLight 750) discontinued
Sign In for Pricing
View Details 
131475-Biotin 100 µL
PLIN1 (Perilipin-1, Lipid Droplet-associated Protein, PERI, PLIN) (Biotin)
Sign In for Pricing
View Details 
039553-ML550 100 µL
OXR1, ID (OXR1, Oxidation resistance protein 1) (MaxLight 550) discontinued
Sign In for Pricing
View Details