E3 Ligase Ligand-linker Conjugate 135

E3 Ligase Ligand-linker Conjugate 135 is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete PROTAC molecule pan-KRAS degrader 5 (HY-168678) [1].

Product Specifications

CAS Number

[3052748-49-6]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugate-135.html

Smiles

O=C(NC1=O)CCC1N(C(N2C)=O)C(C=C3)=C2C=C3N(CC4)CCC4CN(CC5)CCC5CC6CCNCC6

Molecular Formula

C30H44N6O3

Molecular Weight

536.71

References & Citations

[1]"Arvinas Operations, Inc., et al. Preparation of pyridopyrimidines as cereblon-based KRas degrading PROTACS and uses related thereto. World Intellectual Property Organization, WO2024159164 A2 2024-08-02 "