Loteprednol etabonate
Loteprednol etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.Allergy Approved (In Vitro) :Intravenous administration of Loteprednol etabonate (5 mg/kg) to dogs reveals a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect.
Product Specifications
CAS Number
82034-46-6
Product Name Alternative
Loteprednol Etabonate | Lotemax | Alrex | HGP-1 | Loterox | Locort
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 45 mg/mL
Smiles
O=C ([C@@]1 (OC (OCC) =O) CC[C@@]2 ([H]) [C@]3 ([H]) CCC4=CC (C=C[C@]4 (C) [C@@]3 ([H]) [C@@H] (O) C[C@]12C) =O) OCCl
Molecular Formula
C24H31ClO7
Molecular Weight
466.9518
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Androsta-1,4-diene-17-carboxylic acid, 17-[ (ethoxycarbonyl) oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (11β,17α) -
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