Palbociclib hydrochloride
A potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM; no inhibition for CDK2A (IC50>5 uM) ; inhibits MDA-MB453 cells with IC50 of 0.16 uM; shows antiproliferative effect against retinoblastoma (Rb) -positive tumor cells in vitro and reduces the phospho-Ser780/Ser795 on the Rb protein; orally bioavailable.Breast Cancer Approved.
Product Specifications
CAS Number
827022-32-2
Product Name Alternative
PD-0332991 hydrochloride | PD0332991 hydrochloride | PD 0332991 hydrochloride
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 6 mg/mL (Need ultrasonic or warming)
Smiles
Cl.CC (=O) C1=C (C) C2=CN=C (NC3=NC=C (C=C3) N3CCNCC3) N=C2N (C2CCCC2) C1=O
Molecular Formula
C24H30ClN7O2
Molecular Weight
483.9937
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Pyrido[2,3-d]pyrimidin-7 (8H) -one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5- (1-piperazinyl) -2-pyridinyl]amino]-, hydrochloride (1:1)
Available Sizes
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