Delapril?Hydrochloride
Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. (In Vivo) :Delapril (3 mg/kg; administered orally for 2 weeks) exerts potent ACE inhibitory activity in spontaneously hypertensive rat (SHR) .Delapril (1-10 mg/kg; orally) exerts a marked and long-lasting antihypertensive action in various experimental models of hypertension.
Product Specifications
CAS Number
83435-67-0
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
CCOC (=O) [C@H] (CCC1=CC=CC=C1) N[C@@H] (C) C (=O) N (CC (=O) O) C2CC3=CC=CC=C3C2.Cl
Molecular Formula
C26H33ClN2O5
Molecular Weight
489
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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