WIKI4
A novel small molecule inhibitor of the Wnt/β-catenin pathway by inhibiting the enzymatic activity of TNKS2; prevents auto-ADP-ribosylation of TNKS2 with IC50 of 15 nM; inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in cancer cell lines as well as in human embryonic stem cells.
Product Specifications
CAS Number
838818-26-1
Product Name Alternative
WIKI-4
Purity
>98% (HPLC)
Solubility
DMSO: 6.8 mg/mL
Smiles
O=C (NC1=CC=CC=C1C (NC2=CC=C (CCN3CC4=C (C=C (OC) C (OC) =C4) CC3) C=C2) =O) C5=CC=C (OC) C (OC) =C5
Molecular Formula
C29H23N5O3S
Molecular Weight
521.5896
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Benz[de]isoquinoline-1,3 (2H) -dione, 2-[3-[[4- (4-methoxyphenyl) -5- (4-pyridinyl) -4H-1,2,4-triazol-3-yl]thio]propyl]-
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