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GNF-7

A potent and selective type-II kinase inhibitor of Bcr-Abl; inhibits wt Bcr-Abl/T315I Bcr-Abl (IC50< 5 nM) and Bcr-Abl mutants such as G250E, Q252H, Y253H, E255K, E255V, F317L, and M351T in biochemical and cellular assays; displays in vivo efficacy against T315I-Bcr-Abl in xenograft mouse model.

Product Specifications

CAS Number

839706-07-9

Product Name Alternative

GNF 7 | GNF7

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 33 mg/mL

Smiles

O=C (NC1=CC=C (C) C (N2CC3=CN=C (NC4=CC=C (C) N=C4) N=C3N (C) C2=O) =C1) C5=CC=CC (C (F) (F) F) =C5

Molecular Formula

C28H24F3N7O2

Molecular Weight

547.5311

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Benzamide, N-[3-[1,4-dihydro-1-methyl-7-[ (6-methyl-3-pyridinyl) amino]-2-oxopyrimido[4,5-d]pyrimidin-3 (2H) -yl]-4-methylphenyl]-3- (trifluoromethyl) -

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