SC1
Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. (In Vitro) :Pluripotin (SC-1) inhibits Abl1, p70S6K, PLK2, RSK1, RSK2, RSK3, RSK4 with IC50s of 0.005, 1.4, 2.2, 0.5, 2.5, 3.3, 10.0 μM, respectively. Pluripotin (SC-1) decreases cell growth for 7 colon tumor cell lines. After a five day exposure to 0.1 μM SC-1, the seven colon tumor lines are evaluated for changes in cell number and viability. There is a statistically significant decrease in cell number but >95% viability.
Product Specifications
CAS Number
839707-37-8
Product Name Alternative
Pluripotin
Purity
>98% (HPLC)
Solubility
Ethanol: <1 mg/mL; DMSO: 100 mg/mL (181.64 mM) Water: <1 mg/mL
Smiles
O=C (NC1=CC=C (C) C (N2CC3=CN=C (NC4=CC (C) =NN4C) N=C3N (C) C2=O) =C1) C5=CC=CC (C (F) (F) F) =C5
Molecular Formula
C27H25F3N8O2
Molecular Weight
550.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[3-[7- (2,5-Dimethyl-2H-pyrazol-3-ylamino) -1-methyl-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide
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