PRI-724
PRI-724 (PRI724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM, an isomer or enantiomer of ICG-001; binds specifically to the co-activator CBP, but not to p300; selectively induce apoptosis in colon carcinoma cells but not in normal colon cells, and exhibits antitumor activity in the mouse xenograft models of colon cancer.Blood Cancer Phase 2 Clinical.
Product Specifications
CAS Number
847591-62-2
Product Name Alternative
PRI 724 | PRI724
Purity
>98% (HPLC)
Solubility
DMSO: 54.9 mg/mL (100 mM) ; Ethanol: 27.4 mg/mL (50 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
C1CN ([C@H]2CN (C (=O) [C@@H] (N2C1=O) CC3=CC=C (C=C3) O) CC4=CC=CC5=CC=CC=C54) C (=O) NCC6=CC=CC=C6
Molecular Formula
C33H32N4O4
Molecular Weight
548.63
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(6S,9aS) -N-benzyl-6- (4-hydroxybenzyl) -8- (naphthalen-1-ylmethyl) -4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1 (6H) -carboxamide
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