ADL5859

ADL5859 is a potent, selective, orally bioavailable full agonist of δ opioid receptor with Ki of 0.84 nM and EC50 of 20 nM, exhibits >1,000-fold selectivity for δ over μ and κ opioid receptors in both receptor binding and in vitro bioassays; demonstrates analgesic and antidepressive effects in the rat and represent potential drug for chronic pain treatment, significantly reduces inflammatory and neuropathic pain, does not induce either hyperlocomotion or receptor internalization in vivo.Pain Phase 2 Discontinued.