ADL5859
ADL5859 is a potent, selective, orally bioavailable full agonist of δ opioid receptor with Ki of 0.84 nM and EC50 of 20 nM, exhibits >1,000-fold selectivity for δ over μ and κ opioid receptors in both receptor binding and in vitro bioassays; demonstrates analgesic and antidepressive effects in the rat and represent potential drug for chronic pain treatment, significantly reduces inflammatory and neuropathic pain, does not induce either hyperlocomotion or receptor internalization in vivo.Pain Phase 2 Discontinued.
Product Specifications
CAS Number
850173-95-4
Product Name Alternative
ADL-5859 | ADL 5859
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CCN (CC) C (=O) C1=CC=C (C=C1) C2=CC3 (CCNCC3) OC4=CC=CC (=C42) O.Cl
Molecular Formula
C24H29ClN2O3
Molecular Weight
428.9517
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N, N-diethyl-4- (5-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-4-yl) -, hydrochloride (1:1)
Available Sizes
Explore Other Products
Browse additional items from our catalog
Potassium Inwardly Rectifying Channel Subfamily J, Member 10 (KCNJ10), Recombinant, Human, His-Tag
Potassium Inwardly Rectifying Channel Subfamily J, Member 10 (KCNJ10), Recombinant, Human, His-Tag
Potassium Inwardly Rectifying Channel Subfamily J, Member 10 (KCNJ10), Recombinant, Human, His-Tag
Potassium Inwardly Rectifying Channel Subfamily J, Member 10 (KCNJ10), Recombinant, Human, His-Tag
SERGEF (Secretion-regulating Guanine Nucleotide Exchange Factor, Deafness Locus-associated Putative Guanine Nucleotide Exchange Factor, DelGEF, Guanine Nucleotide Exchange Factor-related Protein, DELGEF, GNEFR) (AP) discontinued