Motesanib diphosphate
A potent, orally bioavailable, multikinase inhibitor inhibitor of VEGFR1/2/3, PDGFR and c-Kit with IC50 of 2-6 nM, 84 nM and 8 nM, respectively; also displays activity against Ret (IC50=59 nM), no activities against EGFR, Src, and p38; inhibits human endothelial cell proliferation induced by VEGF, but not by bFGF in vitro; potently inhibits VEGF-induced angiogenesis in the rat models.Lung Cancer Phase 3 Discontinued.
Product Specifications
CAS Number
857876-30-3
Product Name Alternative
AMG-706 | Motesanib | AMG706 | AMG 706
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
OP (O) (O) =O.OP (O) (O) =O.CC1 (C) CNC2=C1C=CC (NC (=O) C1=C (NCC3=CC=NC=C3) N=CC=C1) =C2
Molecular Formula
C22H29N5O9P2
Molecular Weight
569.4413
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-Pyridinecarboxamide, N- (2,3-dihydro-3,3-dimethyl-1H-indol-6-yl) -2-[ (4-pyridinylmethyl) amino]-, phosphate (1:2)
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
