A-740003
A-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively; showed weak or no activity for other P2 receptors (IC50>10 uM) ; potently blocks agonist-evoked IL-1β release (IC50=156 nM) and pore formation (IC50=92 nM) in differentiated human THP-1 cells; produces dose-dependent antinociception in a spinal nerve ligation model (ED50=19 mg/kg i.p.) in the rat.Pain Discontinued.
Product Specifications
CAS Number
861393-28-4
Product Name Alternative
A 740003 | A740003
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC (/N=C (NC#N) \NC1=C2C=CC=NC2=CC=C1) C (C) (C) C) CC3=CC=C (OC) C (OC) =C3
Molecular Formula
C26H30N6O3
Molecular Weight
474.5548
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzeneacetamide, N-[1-[[ (cyanoamino) (5-quinolinylimino) methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxy-
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