Dypyridamole
Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. (In Vitro) :Dipyridamole (5 μM; 15 min) results in a 2.5-fold increase in intracellular cAMP levels in OCI-AML-3 cells.Dipyridamole (5 μM; 48 h) with the statin combination induces apoptosis in primary AML cells.Dipyridamole (5 μM; 48 h) possesse cAMP/PKA-independent activity against statininduced SREBP2 activation. (In Vivo) :Dipyridamole (10 mg/kg; p.o. once daily for 18 d) mitigates tumor growth, ameliorated concurrent alterations in blood circulation and tumor tissues, and platelet infiltration in tumor tissues.
Product Specifications
CAS Number
58-32-2
Product Name Alternative
NSC 515776 | NSC 619103
Purity
>98% (HPLC)
Solubility
Ethanol: 50 mg/mL (99.08 mM) ; DMSO: 101 mg/mL (200.14 mM)
Smiles
OCCN (CCO) C1=NC (N2CCCCC2) =C (N=C (N (CCO) CCO) N=C3N4CCCCC4) C3=N1
Molecular Formula
C24H40N8O4
Molecular Weight
504.63
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,2',2'',2'''- ((4,8-di (piperidin-1-yl) pyrimido[5,4-d]pyrimidine-2,6-diyl) bis (azanetriyl) ) tetraethanol
Available Sizes
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