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IOX1

IOX1 is a potent, broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases, with IC50 of <1 uM gainst the KDM3, KDM4 and KDM6, 5-25 uM against the KDM5 and KDM2/7; IOX1 is less potent against BBOX1 (IC50=196 uM) ; chelates to Fe (II) in the active site of 2OG oxygenases; suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II.

Product Specifications

CAS Number

5852-78-8

Product Name Alternative

IOX 1 | IOX-1

Purity

>98% (HPLC)

Solubility

DMSO: 24 mg/mL

Smiles

O=C (C1=C2C=CC=NC2=C (O) C=C1) O

Molecular Formula

C10H7NO3

Molecular Weight

189.1675

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

5-Quinolinecarboxylic acid, 8-hydroxy-

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