Etacrynic acid
A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue; shows anticancer activity, and also is a potent inhibitor of glutathione S-transferase; shows antitumor effects and may enhance the cytotoxicity of chemotherapeutic agents by binding to glutathione and inhibiting WNT signaling.Other Indication Phase 2 Clinical.
Product Specifications
CAS Number
58-54-8
Product Name Alternative
Edecrin
Purity
>98% (HPLC)
Solubility
Ethanol: 30 mg/mL; DMSO: 30 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
CCC (=C) C (=O) C1=C (C (=C (C=C1) OCC (=O) O) Cl) Cl
Molecular Formula
C13H12Cl2O4
Molecular Weight
303.135
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Acetic acid, [2,3-dichloro-4- (2-methylene-1-oxobutyl) phenoxy]- (9CI)
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