Losmapimod
Losmapimod (GSK-AHAB, GW856553X, SB856553) is a selective, potent, orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively; displays no significant activity for p38γ, p38δ (<25% inhibition at 10 uM), and COX-2; significantly and dose-dependently improves survival, endothelial-dependent and -independent vascular relaxation in rat model of cardiovascular disease.Ischemia Phase 3 Clinical (In Vitro) :In the spontaneously hypertensive stroke-prone rat (SHR-SP), chronic treatment with GSK-AHAB significantly and dose-dependently improves survival, endothelial-dependent and -independent vascular relaxation, and indices of renal function, and it attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, and interleukin-1β (IL-1β) .
Product Specifications
CAS Number
585543-15-3
Product Name Alternative
GSK-AHAB | GW856553X | SB856553 | GW 856553X | SB 856553
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 58 mg/mL
Smiles
O=C (C1=CC=C (C2=CC (C (NC3CC3) =O) =CC (F) =C2C) N=C1) NCC (C) (C) C
Molecular Formula
C22H26FN3O2
Molecular Weight
383.4591
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-Pyridinecarboxamide, 6-[5-[ (cyclopropylamino) carbonyl]-3-fluoro-2-methylphenyl]-N- (2,2-dimethylpropyl) -
Available Sizes
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