Fexinidazole
Fexinidazole is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologically relevant active metabolites in vivo are the sulfoxide and sulfone. (In Vitro) :Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested. (In Vivo) :Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities.
Product Specifications
CAS Number
59729-37-2
Product Name Alternative
Fexinidazole | Hoe-239 | Hoe 239 | Hoe239
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM
Smiles
O=[N+] (C1=CN=C (COC2=CC=C (SC) C=C2) N1C) [O-]
Molecular Formula
C12H13N3O3S
Molecular Weight
279.31
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Methyl-2- ((p- (methylthio) phenoxy) methyl) -5-nitroimidazole
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