Malotilate
Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis. (In Vitro) :Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro.Malotilate, an anti-fibrotic substance, selectively inhibited the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways are stimulated. Malotilate has been shown to prevent acute experimental liver injury induced by several hepatotoxic compounds, including Ahyl alcohot, Bromobenzene, Carbon tetrachloride, ChIoroform, Dimethylnitrosamine and Thioacetamide. (In Vivo) :Malotilate (100 mg/kg; p.o.; daily for 3 days) treatment in rats with hypocholesterolemia results in a rapid normalization of lowered serum cholesterol.
Product Specifications
CAS Number
59937-28-9
Product Name Alternative
Malotilate | CL-1500 | NKK 105 | NKK-105
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 58 mg/mL (201.12 mM) ; DMSO: 58 mg/mL (201.12 mM)
Smiles
O=C (OC (C) C) /C (C (OC (C) C) =O) =C1SC=CS/1
Molecular Formula
C12H16O4S2
Molecular Weight
288.38
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,3-Dithiol-2-ylidenepropanedioic acid, bis (1-methylethyl) ester
Available Sizes
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