Ebselen
Ebselen is a mimic of glutathione peroxidase and can also react with peroxynitrite. It is being investigated as a possible treatment for reperfusion injury and stroke, hearing loss and tinnitus, and bipolar disorder. (In Vitro) :Ebselen (SPI-1005; 0.4-100 μM; 20-24 hours) shows strong antiviral effects at a concentration of 10 μM treatment in COVID-19 virus infected Vero cells. Ebsele covalently binds to C145 of the catalytic dyad in COVID-19 virus Mpro.Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process.Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. Ebselen inhibits inositol monophosphatase (IMPase) .Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic, renal cancer cell lines. (In Vivo) :Ebselen (5, 10 mg/kg; IP) decreases 5-HT2 agonist-induced head twitches in a dose-dependent manner.
Product Specifications
CAS Number
60940-34-3
Product Name Alternative
SPI-1005 | SPI1005 | SPI 1005 | Ebselen | PZ 51 | PZ51 | PZ-51 | DR3305 | DR 3305 | DR-3305
Purity
>98% (HPLC)
Solubility
Water: 10 mM
Smiles
O=C1N (C2=CC=CC=C2) [Se]C3=CC=CC=C13
Molecular Formula
C13H9NOSe
Molecular Weight
274.18
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-phenylbenzo[d][1,2]selenazol-3 (2H) -one
Available Sizes
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