AKT inhibitor VIII
A selective, allosteric Akt inhibitor with IC50 of 58/210 for Akt1/2 respectively; shows weak activity for Akt3 (IC50=2.12 uM) ; inhibits basal and IGF stimulated Akt1 and Akt2 phosphorylation in mouse lung, with no effect on Akt3 phosphorylation.
Product Specifications
CAS Number
612847-09-3
Product Name Alternative
AKT inhibitor VIII | AKT-inhibitor-VIII | AKT inhibitor-8 | AKT-inhibitor-8 | Akt-I 1,2 | Akti-1/2. Sigma-A6730
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C1N (C2CCN (CC3=CC=C (C4=NC5=CC6=C (N=CN6) C=C5N=C4C7=CC=CC=C7) C=C3) CC2) C8=CC=CC=C8N1
Molecular Formula
C34H29N7O
Molecular Weight
551.6404
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[[4- (6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl) phenyl]methyl]-4-piperidinyl]-
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