Ki20227
A potent, selective, orally active c-Fms inhibitor with IC50 of 2 nM; weakly inhibits KDR, c-Kit, and PDGFRβ with IC50 of 12, 451, and 217 nM, respectively, no activty against Flt-3, c-Src, Fyn, EGFR, FGFR2, Met, Btk, PKA, and PKCα (IC50>1,000 nM) ; inhibits the M-CSF-dependent cell growth, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.
Product Specifications
CAS Number
623142-96-1
Product Name Alternative
Ki 20227 | Ki-20227
Purity
>98% (HPLC)
Solubility
DMSO: 7.2 mg/mL
Smiles
O=C (NC (C1=NC=CS1) C) NC2=CC=C (OC3=CC=NC4=CC (OC) =C (OC) C=C34) C=C2OC
Molecular Formula
C24H24N4O5S
Molecular Weight
480.5362
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Urea, N-[4-[ (6,7-dimethoxy-4-quinolinyl) oxy]-2-methoxyphenyl]-N'-[1- (2-thiazolyl) ethyl]-
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